Systemic Dickkopf-related Protein 1 (DKK1)During Estrogen Level Changes in Post-menopausal Breast Cancer Patients Treated With Aromatase Inhibitors

Exclusion Criteria

• •BMI \>30 or \<18
• •Osteoporosis as defined by protocol.
• •Subjects currently on bisphosphonate therapy.
• •History of primary or secondary hyperparathyroidism
• •History of Hypo-or Hyperthyroidism
• •History of Vitamin D levels below LLN
• •History of creatinine clearance below the EGFR
• •History ofLiver function tests above 1.5 times ULN including LDH, SGOT, SGPT, Alkaline phosphatase, and Bilirubin
• •History of documented cirrhosis of the liver
• •History of chronic heparin use
• •History of chronic glucocorticoid therapy