Lead Sponsor

Sheffield Teaching Hospitals NHS Foundation Trust

Collaborators

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Yes

•Willing to participate
•Able to give informed consent
•Patient with carcinoid syndrome-active disease (untreated or receiving medical treatment)
•or
•Healthy volunteer who adequately matches a patient with carcinoid syndrome gender, age (±5 years), height (±5cm) and BMI(±3 kg/m2)

•Curative surgery for carcinoid disease
•Body weight over 159 kg (weight limit for DXA measurement of BMD)
•Previous orthopaedic surgery or fractures which preclude imaging at all sites
•History of any long term immobilization (duration greater than three months)
•Fracture less than one year prior to recruitment
•Current pregnancy or trying to conceive
•Delivery of last child less than one year prior to recruitment
•Breast feeding less than one year prior to recruitment
•History of, or current conditions known to affect bone metabolism
•* Diagnosed skeletal disease or inflammatory arthritis
•* Chronic renal disease
•* Malabsorption syndromes
•* Other diagnosed endocrine disorders
•* Hypocalcemia or hypercalcemia
•* Diagnosed restrictive eating disorder
•* Diabetes mellitus
•Conditions or surgery which prevent the acquisition or analysis of DXA, VFA or HR-pQCT
•Use of medications or treatment known to affect bone metabolism
•Alcohol intake greater than 21 units per week

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