Colorectal cancer screening is recommended for average-risk persons beginning at age 50. A family history of colorectal cancer is recognized as a risk factor for colorectal adenoma. However, the strength of this association is uncertain. Current guidelines for initiating screening colonoscopies in patients younger than 50 years of age who have a first relative history of colorectal cancer have proved controversial. The conflicting recommendations are partly attributable to the lack of data about the prevalence of CRC and adenomas among 30- to 49-year-old individuals with a first relative history of colorectal cancer. This prospective study will quantify the prevalence of adenomas (any size) and advanced adenomas among 30- to 49-year-old individuals undergoing their first screening colonoscopy because of a first relative history of colorectal cancer and compare the data with controls(asymptomatic subjects without a first relative history of colorectal cancer).
Age
30–49
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
30- to 49-year-old asymptomatic subjects
First relative history of colorectal cancer
You may not be if
previous colonoscopy for any reason
personal history of colorectal adenomas or CRC
history of familial adenomatous polyposis, hereditary nonpolyposis colorectal cancer, or inflammatory bowel disease
documented history of occult GI bleeding, lower gastrointestinal tract bleeding not attributable to hemorrhoid, or
iron deficiency anemia
unexplained weight loss of \>10% of the body weight in the 6 months before colonoscopy
incomplete examination of entire colon
Clareo Health | Study of Prevalence of Colorectal Adenoma in 30- to 49-year-old Subjects With a Family History of Colorectal Cancer
