Analgesic Efficacy and Management of Opioid-induced Constipation (OIC) for Uncontrolled Moderate - Severe Low Back Pain

Exclusion Criteria

• •Subjects with rheumatoid arthritis or other inflammatory arthritis;
• •Subjects with neuropathic conditions that have been painful or required therapy within the past 3 months;
• •Subjects with evidence of significant structural abnormalities of the gastrointestinal (GI) tract or other significant conditions affecting GI motility;
• •Subjects with chronic constipation not related to opioid use;
• •Subjects who had surgical procedures directed towards the source of chronic low back pain within 6 months of the screening visit or planned during the study;
• •Subjects with a history of malignancy within the past 2 years, with the exception of basal cell carcinoma that has been successfully treated.