Ketogenic Diet With Chemoradiation for Lung Cancer (KETOLUNG)

Inclusion Criteria

• •Histologically or cytologically documented NSCLC.
• •Candidate for primary chemoradiation as decided by both medical and radiation oncology.
• •Cancer should be staged via AJCC as IIIA or IIIB.
• •Stage IV patients are considered provided they have a single non-CNS metastasis (that is amenable to treatment with radiation therapy).
• •Age ≥ 18 years
• •ECOG performance status 0-2 (Karnofsky \> 50%, see Appendix A).
• •Hypertensive medication should be initiated or increased for optimal blood pressure control according to standard public health guidelines prior to starting the ketogenic diet.
• •Patients must have normal organ and marrow function as defined below:
• •leukocytes ≥ 3,000/mm3
• •absolute neutrophil count ≥ 1,500/mm3
• •platelets ≥ 100,000/mm3
• •total bilirubin \< 1.5 mg/dl
• •Hgb A1C \< or = to 8%
• •AST(SGOT) \< or = to 2 X institutional upper limit of normal
• •creatinine \< 1.5 X institutional upper limit of normal OR creatinine clearance ≥ 60 mL/min/1.73 m2 for patients with creatinine levels above institutional normal.
• •Not pregnant. Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately.
• •Ability to understand and the willingness to sign a written informed consent document.