Effects of Pre-, Pro- & Anti-biotics on Gut Microbiota

Exclusion Criteria

• •Any diagnosed autoimmune disease
• •History of organ transplantation
• •Known chronic or recurrent systemic disorder associated with immunocompromise
• •A history of allergy or hypersensitivity to mushroom or mushroom extract, brewer's or baker's yeast or to penicillins or cephalosporins (including amoxicillin).
• •History of severe allergic reaction (requiring hospital admission and/or the administration of parenteral medication or associated with dyspnoea, wheezing, hypotension, loss of consciousness).
• •Systemic antibacterial therapy during the 3 months prior to study enrollment
• •New prescription medications during the 4 weeks prior to study enrollment
• •Prescription or OTC medications or supplements that are known to alter gut function or microflora (i.e. acid antisecretory drugs, probiotics) during the 4 weeks prior to study enrollment
• •Active gastrointestinal or metabolic disease
• •Prior gastrointestinal surgery (apart from appendectomy or cholecystectomy)
• •History of chronic constipation with passage of fewer than 3 spontaneous bowel movements per week on average or chronic or recurrent diarrhea with spontaneous bowel movements more often than 3 times daily
• •Any condition or personal circumstance that, in the opinion of the investigator, renders the subject unlikely or unable to comply with the full study protocol.