A Study of Cariprazine in the Prevention of Relapse of Symptoms in Participants With Schizophrenia

There were 3 periods (phases) in the study. The Open-label Phase lasted 20 weeks. In the first 6 weeks, participants received 3, 6, or 9 mg cariprazine orally once a day; the dose could be modified during this time. The cariprazine dose was fixed at 3, 6, or 9 mg for the last 14 weeks of this Open-label Phase. At the end of Week 8, participants had to meet the following criteria to continue in the study. * Positive and Negative Syndrome Scale (PANSS) total score ≤ 60 at the end of Week 8 * At least 20% decrease in PANSS total score from baseline to the end of Week 8 * Clinical Global Impressions - Severity (CGI-S) score ≤ 4 at the end of Week 8 * Score of ≤ 4 on each of the following 7 PANSS items: P1, P2, P3, P6, P7, G8, and G14 at the end of Week 8 * Stable dose during the previous 2 weeks * No significant tolerability issues as judged by the Investigator at the end of Week 8 At the end of the Open-label Phase, participants were randomized into 2 treatment groups, cariprazine or placebo, if they met the following criteria: * PANSS total score ≤ 60 at the end of Week 20 * At least 20% decrease in PANSS total score from baseline to the end of Week 20 * CGI-S score ≤ 4 at the end of Week 20 * Score of ≤ 4 on each of the following 7 PANSS items: P1, P2, P3, P6, P7, G8, and G14 at the end of Week 20 * No significant tolerability issues as judged by the Investigator During this Double-blind Treatment Phase, participants received either placebo or cariprazine at the same dosage (3, 6, or 9 mg) that they received during the last 14 weeks of the Open-label Phase. All participants entered the 4 week Safety Follow-up Phase. They received a treatment other than the investigational product at the discretion of the Investigator.