Subjects will receive their transplants as in-patients.
* IV-Catheter
* one or two IV catheters will be placed on the day of hospital admission
* Conditioning
* Fludarabine IV six days before transplant (days -7, -6, -5. -4, -3, -2)
* Melphalan IV (day -1)
* Total body radiation on day 0 (same day as transplant)
* Immunosuppressive Therapy
* Tacrolimus and sirolimus beginning day -3, daily for 6-9 months post-transplant. Given IV as in-patient, orally as out-patient
* Infusion of Cord Blood units
* 2 cord blood units IV on Day 0 Routine post-transplant supportive care will be provided
