Reduced Intensity Double Umbilical Cord Blood Transplantation

Subjects will receive their transplants as in-patients. * IV-Catheter * one or two IV catheters will be placed on the day of hospital admission * Conditioning * Fludarabine IV six days before transplant (days -7, -6, -5. -4, -3, -2) * Melphalan IV (day -1) * Total body radiation on day 0 (same day as transplant) * Immunosuppressive Therapy * Tacrolimus and sirolimus beginning day -3, daily for 6-9 months post-transplant. Given IV as in-patient, orally as out-patient * Infusion of Cord Blood units * 2 cord blood units IV on Day 0 Routine post-transplant supportive care will be provided