Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Calgary
PRIMARY AIM: To examine whether the physiologic and molecular responses to Angiotensin II (AngII) challenge differ in response to fructose intake as assessed by two independent means:
1. The renal and mean arterial pressure (MAP) response to an AngII challenge.
2. Reactive changes in circulating levels of renin and aldosterone with graded AngII challenge.
PRIMARY HYPOTHESES: Ingestion of fructose in healthy subjects will result in:
1. A decrease in renal and systemic sensitivity to infused AngII.
2. A decrease in the reactive changes in renin and aldosterone with graded AngII challenge.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
age≥18 years,
able to comprehend study and comply with high-salt diet
kidney disease (on the approval of their nephrologist)
on an oral birth control pill and non oral birth control and those not on birth control
You may not be if
cardiovascular disease (symptoms consistent with myocardial ischemia, previously documented myocardial ischemia, cardiac arrhythmias or valve abnormalities, or abnormal ECG at screening)
cerebrovascular disease (transient ischemic attacks or stroke)
hypertension (BP\>140/90 or use of antihypertensive medications)
diabetes mellitus (defined by history, use of hypoglycemic agents or a fasting glucose \>7mmol/L)
hyperlipidemia (LDL \>4.5mmol/L or use of lipid-lowering agents)
