Physiologic Investigation of the Renin Angiotensin Aldosterone Axis in HIV

Exclusion Criteria

• •1. Antihypertensive use, including angiotensin converting enzyme inhibitors or angiotensin II receptor blocker use, diuretics, beta-blockers, calcium-channel blockers, potassium supplements, and spironolactone; and/or blood pressure (BP) \>140/90 at screen
• •2. Current or recent steroid use within last 2 months.
• •3. Known diabetes and/or use of antidiabetic medications
• •4. Creatinine \> 1.5 mg/dL
• •5. Potassium (K) \> 5.5 mEq/L
• •6. Hemoglobin (Hgb) \< 11.0 mg/dL
• •7. Alanine aminotransferase (ALT) \> 2.5 x upper limit of normal (ULN)
• •8. Thyroid disease/abnormal thyroid stimulating hormone (TSH)
• •9. Significant electrocardiographic abnormalities at screen such as heart block or ischemia
• •10. History of congestive heart failure, stroke, myocardial infarction, or known coronary artery disease (CAD)
• •11. For women: Pregnant or actively seeking pregnancy, or breastfeeding
• •12. Estrogen, progestational derivative, growth hormone (GH), growth hormone releasing hormone (GHRH) or ketoconazole use within 3 months.
• •13. Current viral, bacterial or other infections (excluding HIV)
• •14. Current cigarette smoker/use of nicotine (patch/gum) or current active substance abuse