Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Massachusetts General Hospital
Age
18–45
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
Age 18-45 years
AN defined by DSM-IV diagnostic criteria, including weight less than 85% of ideal body weight (restricting or binge/purge type, BMI 15-17.5) OR meet criteria for sub-threshold AN, i.e., all DSM-IV criteria except that patients can have a BMI of \<18.5 kg/m2 with or without amenorrhea
Oral contraceptive use prior to enrollment
BMD T score \< -1.0
Normal FSH and TSH or free T4
Normal serum 25-OH vitamin D (\>20 ng/mL) and calcium levels
Ongoing care from a primary care provider
Agree to use barrier contraception
You may not be if
Any subject with contraindications to risedronate
Any subject with binge-purge subtype of anorexia nervosa who vomits regularly as their form of purging (vs. those who use laxatives or diuretics) and who have significant periodontal disease, tooth erosion or an invasive dental or periodontal procedure within the previous three months.
Any disease known to affect bone, including untreated thyroid dysfunction, Cushing's or renal failure
Any medication known to affect bone metabolism within 3 months of the study, excluding oral contraceptives. Bisphosphonates must have been discontinued for at least one year before participation
Serum potassium \<3.0 meq/L
Serum ALT \>3 times upper limit of normal
eGFR of less than 30 ml/min
Pregnant and/or breastfeeding
Diabetes mellitus
Active substance abuse, including alcohol
History of malignancy
Atraumatic fracture within the prior year
Clareo Health | IGF-1 and Bone Loss in Women With Anorexia Nervosa
