Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Astellas Pharma Inc
Age
50–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Subject has a Mini-Mental Status Exam score of 18-26
Subject has a diagnosis of "probable" Alzheimer's Disease
Subject has used donepezil for at least 3 months and has been on a stable dose for at least 6 weeks prior to screening
Subject has a reliable adult who is residing with him/her during the outpatient portion of the study
Subject is medically stable
Subject has adequate cognitive, hearing, vision, and language skills
Subject is able to ingest oral tablets
You may not be if
Subject has received any investigational product in another clinical study or post-marketing clinical study within past 3 months
Subject has any clinically significant abnormal laboratory tests
Subject is a female who is pregnant, lactating or of childbearing potential who refuses to use a form of contraception during the study
Subject has a history of a drug allergy or intolerance to memantine or a related compound
Subject is currently using anti-dementia drugs (except for donepezil) or has used any such drugs within the last 4 weeks
Subject has a score of 2 on item 16 of Cornell Scale for Depression in Dementia (CSDD) or has an overall CSDD score \> 10
Subject is using off-label medicines, non-medicinal compounds, or dietary aids/food supplements to improve cognition that have not been at a stable dose for at least 4 weeks prior to Screening and/or are anticipated to change dosing regimen during the study
Subject has a history of drug or alcohol abuse within the past 12 months or subject consumes \> 1 drink of alcohol daily, or is unable to refrain from alcohol during the study
Subject is a current smoker or recently quit smoking (within the past 12 months)
Subject has a clinically significant medical condition that is unstable or is likely to become unstable during the course of the study
Subject has history of seizures, other than febrile seizures during infancy
Subject has history of repeated falls within past 6 months
Subject has a major psychiatric illness or has received treatment for symptoms of a major psychiatric illness within past 1 year. Mild psychiatric disorders are allowable
