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Study of Arimidex and Radiotherapy Sequencing | Clinical Trials | Clareo Health

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UNKNOWNPhase 3NCT01402193

Study of Arimidex and Radiotherapy Sequencing

The purpose of this study is to compare TGF-β1 change in concomitant with that in sequential Arimidex in postmenopausal women with breast cancer, as measured by the proportion of patients with an elev...

Lead sponsor: Fudan University•1 locations•View source on ClinicalTrials.gov

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Contacts

Jiayi Chen, MD

CONTACT

Sponsors

Lead Sponsor

Fudan University

Collaborators

AstraZeneca

Age

18 - 70 years

Sex

FEMALE

Healthy Volunteers

No

Inclusion Criteria

•Provision of informed consent
•Pathological confirmation of breast cancer
•ER(+) and/or PR(+).
•Post-menopausal woman
•Age≤70 years old
•Breast conservative surgery with axillary dissection or staging by either sentinel nodes biopsy or axillary sampling
•Post-mastectomy patients with T1-T2 and N1-N3, or T3-T4 with any N Negative surgical margins
•Karnofsky≥70
•Laboratory criteria:
•* PLT≥100\*109/L
•* WBC≥4000/mm3
•* HGB≥10g/dl
•* ALT and AST\<2\*ULN
•No presence of metastatic disease
•No other malignant tumour

Exclusion Criteria

•Presence of metastatic disease.
•T1, T2, N0 with mastectomy
•Non-infiltrative breast carcinoma underwent mastectomy
•Other malignant tumor (concurrent or previous).
•Positive surgical margins.
•Patients with demonstrated hypersensitivity to Arimidex or any excipient.
•Patients with severe renal impairment (creatinine clearance less than 20 ml/min).
•Patients with moderate or severe hepatic disease.
•Oestrogen-containing therapies should not be co-administered with Arimidex as they would negate its pharmacological action.
•Not able or willing to sign informed consent
•Autoimmune diseases including scleroderma, systemic lupus erythematosus and so on

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: June 25, 2014Terms

Trial snapshot

StatusUNKNOWN

PhasePHASE3

Enrollment220

Start dateJul 2011

Last updatedJun 25, 2014

Condition

Locations shown

Fudan University Cancer Hospital

Shanghai, Shanghai Municipality

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: June 25, 2014Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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