Safety & Efficacy WC3011 (Estradiol Vaginal Cream) in the Treatment of Vulvovaginal Atrophy in Postmenopausal Women

Exclusion Criteria

• •Hypersensitivity to estrogen and/or progestin therapy
• •Known or suspected premalignant or malignant disease (except successfully treated skin cancers)
• •Manifestation of or treatment for significant cardiovascular disease, congestive heart failure, stroke or ischemic attacks
• •Insulin-dependent diabetes mellitus
• •Increased frequency or severity of headaches while on hormone or estrogen therapy
• •Drug or alcohol addiction within last 2 years
• •Participation in a clinical trial within 30 days
• •Smoking ≥ 15 cigarettes daily
• •Uncontrolled hypertension - systolic blood pressure (BP) ≥ 160 mmHg or diastolic BP ≥ 95 mmHg