Sorafenib Maintenance Therapy for Patients With AML After Allogeneic Stem Cell Transplant

Subjects will taken sorafenib orally either once or twice daily. Subjects will come to the Bone Marrow Transplant Clinic 3 times (on Day 8, 15, and 30) during the first month of treatment. After the first month, they will be seen every month for 3 months and then at 9 at 6 and 9 months. Subjects will have a physical exam and be asked questions regarding general health and specific questions about any problems they might be having and any medications they are taking. Subjects will have standard blood tests every month for 12 months to check liver and kidney function and complete blood count. Subjects will have research blood tests on Days 8, 15 and 30 during the first month of treatment. Subjects will have a bone marrow biopsy after 3 months and 12 months of treatment. Subjects will receive treatment for up to 12 months and be followed for 1 year after completing the study.