Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Children's Hospital of Philadelphia
With
Genzyme, a Sanofi Company
To quantify the amount of fat in the bone marrow of affected subjects and healthy controls the investigators will use Single voxel short, echo time(TE) proton spectroscopy. This MR Spectroscopy (MRS) will be conducted in the vertebral body of L5 and in the neck of the femur.
To assess the qualitative scores and compare it to the quantitative MR Spectroscopy (MRS) results the investigators will use a series of Fluid sensitive and Fat sensitive conventional MR sequences that will allows us to determine indirectly the degree of glucocerebrosidase infiltration.
Age
5–20
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Confirmed diagnosis of Gaucher disease / age and gender match control
Children aged 5-20 yrs
Parental consent
Child assent if appropriate
You may not be if
Presence of medical illness or exposure to drugs that alter the appearance of bone marrow on MRI
