Effects of Pioglitazone, a PPARgamma Receptor Agonist, on the Abuse Liability of Oxycodone

Exclusion Criteria

• •1. Physical dependence on any drugs, excluding nicotine and caffeine
• •2. Participants requesting treatment
• •3. Participants on parole or probation
• •4. Pregnancy or lactation: Female participants must agree to the use of a barrier control method of contraception (e.g. male and female condoms, diaphragms, cervical caps and contraceptive sponges used in combination with spermicide)
• •5. Current or recent history of significant violent behavior (within the past 6 months)
• •6. Current major Axis I psychopathology that might interfere with ability to participate in the study
• •7. Significant suicide risk
• •8. Current chronic pain
• •9. Current or history of congestive heart failure, edema, or diabetes mellitus
• •10. Sensitivity, allergy, or contraindication to opioids or pioglitazone
• •11. Unstable physical disorders that might make participation hazardous, such as end-stage AIDS, hypertension (blood pressure \> 140/90), or heart disease (please note that participants will be asked about previous visits to a cardiologist, chest pain, or strong palpitations; if these exist, they will be referred to a cardiologist and excluded unless cleared for participation by a cardiologist)