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Effect of N-acetylcysteine on Prevention of Acute Kidney Injury in High Risk Patients Undergoing Off-pump Coronary Artery Bypass Graft | Clinical Trials | Clareo Health

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Effect of N-acetylcysteine on Prevention of Acute Kidney Injury in High Risk Patients Undergoing Off-pump Coronary Artery Bypass Graft

NCT01394419•Yonsei University

View on ClinicalTrials.gov

Summary

N-acetylcysteine may prevent acute kidney injury in high risk patients undergoing off-pump coronary artery bypass graft.

Eligibility

Age

20 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patients undergoing off-pump coronary artery bypass surgery and meets more than one of the following criteria;
•* preoperative serum creatinine \> 1.4 mg/dl
•* Age \> 70 years
•* Diabetes mellitus
•* left ventricular ejection fraction \< 35 % or congestive heart failure (NYHA III or IV)
•* emergency surgery or re-operation

Exclusion Criteria

•preoperative acute renal failure, patients on dialysis, use of N-acetylcystein within 5 days of surgery, history of hypersensitivity to N-acetylcystein

Locations (1)

Severance Hospital

Seoul, South Korea

Key Dates

Start Date

September 1, 2010

Primary Completion Date

April 1, 2012

Completion Date

April 1, 2012

Last Updated

March 6, 2013

Enrollment

115

ACTUAL participants

Conditions

Postoperative Acute Kidney Injury After Off-pump Coronary Artery Bypass Graft

Interventions

N-acetylcysteine

DRUG

Saline

DRUG