Participation in a pulmonary rehabilitation program or in any supervised exercise program during the 4 months prior to screening

More than 4 exacerbations in the year prior to screening

Life-threatening exacerbation in the year prior to screening

Requirement for long-term oxygen therapy (\> 12 hours of oxygen per day)

Critical illness or co-morbid conditions that may interfere with study conduct or endpoint measurements

Use of agents known to increase lean body mass within 3 months prior to screening

Hypopituitarism, history of pituitary tumor/surgery, head irradiation, or severe head trauma

Efficacy and Safety Study of Tesamorelin in Chronic Obstructive Pulmonary Disease (COPD) Subjects With Muscle Wasting