Vorinostat With or Without Bortezomib in Treating Patients With Refractory or Recurrent Stage IIB, Stage III, or Stage IV Cutaneous T-Cell Lymphoma

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically confirmed advanced cutaneous T-cell lymphoma (CTCL), including its variants mycosis fungoides and Sézary syndrome
• * Stage IIB-IV disease
• Relapsed or refractory disease, including any of the following:
• * Patients with clinical progression following EORTC-21081 protocol treatment
• * Intolerant to ≥ 1 prior intravenous chemotherapy, including denileukin diftitox, antibodies or antibody conjugates, or any other systemic therapy
• No CNS involvement
• PATIENT CHARACTERISTICS:
• WHO performance status 0-2
• Absolute neutrophil count \> 1.5 x 10\^9/L\*
• Platelet count \> 100 x 10\^9/L\*
• Hemoglobin \> 9 g/dL\*
• WBC \> 3 x 10\^9/L\*
• Bilirubin ≤ 1.5 times upper limit of normal (ULN)\*
• AST and ALT ≤ 3 times ULN (in case of liver infiltration ≤ 5 x ULN)\*
• Serum creatinine ≤ 2.0 mg/dL\*
• Calculated creatinine clearance ≥ 60 mL/min
• Electrolytes (including potassium and magnesium) ≤ 1 times ULN\*
• Not pregnant or nursing prior to the first dose of study treatment and until 4 weeks after the last study treatment
• Negative pregnancy test
• Fertile patients must use effective contraception during and for 3 months after completion of study therapy
• Able to swallow capsules and is able to take or tolerate oral medication on a continuous basis
• No New York Heart Association class III-IV disease
• None of the following known conditions:
• * Infectious disease
• * Autoimmune disease
• * Immunodeficiency
• No known or active HIV and/or hepatitis A, B, or C infection
• No NCI CTC grade 1 peripheral sensory neuropathy with pain or peripheral sensory or motor neuropathy ≥ grade II
• No other malignancy within the past 5 years
• No psychological, familial, sociological, or geographical condition potentially hampering compliance with the study protocol and follow-up schedule NOTE: \*Patients with a buffer range from the normal values of +/- 5% for hematology and +/- 10% for biochemistry are acceptable, except for renal function.
• PRIOR CONCURRENT THERAPY:
• See Disease Characteristics
• Must have completely recovered from previous treatment toxicity
• No prior splenectomy or splenic irradiation
• No prior bortezomib and/or histone deacetylase inhibitors (including vorinostat \[SAHA\])
• More than 4 weeks since prior chemotherapy, immunotherapy, radiotherapy, or surgery
• * In case of clear progression during previous treatment, 2 weeks of wash-out is enough
• No concurrent chemotherapy, immunotherapy, radiotherapy, or surgery (except biopsies)
• No concurrent steroid (prednisone or equivalent) dose \> 20 mg/day
• * Prednisone ≤ 20 mg/day for treatment of disorders other than CTCL allowed
• No concomitant use of other histone deacetylase inhibitors (e.g., valproic acid)