Cryo-Touch III Refinement Study Investigational Plan

Exclusion Criteria

• •Subject takes any medication or dietary supplement regularly that affects blood clotting (e.g., Coumadin, aspirin, clopidogrel) or increases the risk of bleeding/bruising
• •Subject has had prior surgery that alters the subcutaneous anatomy of the target treatment sites
• •The investigator is unable to substantially lessen facial lines by physical separation
• •Subject has undergone another facial cosmetic procedures at or above the level of the cheekbones within the past 6 months
• •Subject is participating in another facial cosmetic research study
• •Patient has any of following conditions:
• •History of facial nerve palsy
• •Marked facial asymmetry
• •Ptosis
• •Excessive dermatochalasis
• •Deep dermal scarring
• •Thick sebaceous skin
• •History of neuromuscular disorder
• •Chronic dry eye symptoms
• •Allergy or intolerance to lidocaine
• •Other local skin condition (eg, skin infection) at target treatment site
• •Any physical or psychiatric condition that in the investigator's opinion would prevent adequate study participation