Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Royan Institute
In the clinical trial 30 patients with multiple sclerosis who are drug resistance will take apart.Based on inclusion and exclusion criteria patients are chosen.Bone marrow aspiration will be done for all of them under local anesthesia.Patients are randomly divided in 2 groups:case and control. Then mesenchymal stem cells which are separated and prepared will be transplanted by intravenous injection to the patients in case group and the cells which obtain from patients in control group are frozen and inject after 6 months. Patients will be followed by Evaluation of EDSS MSFC RAO Test brain and cervical MRI and quality of life questionnaire after 1th 3th 6th and 12th months after transplantation.all these tests will be done before transplantation as basic evaluation.
Age
18–55
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Both gender
Age: 18-55years
Duration of disease: 2-10 years
Relapsing remitting with drug resistance
EDSS: 3-6.5
Resistance to immunomodulatory and cytotoxic drugs:
* At least 1-2 sever relapse during 1 year drug treatment
* At least increase 1 point of EDSS during 1 year drug treatment
Secondary progressive or relapsing multiple sclerosis
Primary progressive MS with relapse or GAD positive enhancement
Secondary progressive MS with relapse
Secondary progressive MS without relapse:progression of disease with 1 point increase of EDSS during last 18 months
You may not be if
Pregnancy positive test
Under treatment with cytotoxic drugs at the same time or during last 3 months
Under treatment with immunomodulatory drugs at the same time or during last month
Relapse of disease 30 days or less than 30 days before transplantation
Primary progressive MS with out relapse or GAD positive enhancement
Clareo Health | Evaluation of Autologous Mesenchymal Stem Cell Transplantation (Effects and Side Effects) in Multiple Sclerosis
