Rheumatoid Arthritis Treatment and Biopsy Study Assessing Certolizumab Pegol (Cimzia)

Inclusion Criteria

• •Signed and dated informed consent document
• •Subjects must be at least 18 years of age or older
• •Subject must be willing and able to comply with scheduled visits, arthroscopy, laboratory tests, and other procedures
• •Diagnosis of RA based on American College of Rheumatology (ACR) 1987 Revised Criteria
• •Active disease at screening visit
• •Methotrexate taken continuously for at least 12 weeks at a stable dosage
• •Sexually active women of child-bearing potential and men whose partners are women of child-bearing potential are required to use adequate contraceptive methods during participation on this trial
• •Treatment with non-steroidal anti-inflammatory drugs (NSAIDS)and oral corticosteroids (less than or equal to 10 mg/day prednisone or equivalent)is accepted