A Study of Terlipressin in Patients With Hepatorenal Syndrome Type 1

Inclusion Criteria

• •\- Patients who were diagnosed with HRS type 1 according to the diagnostic criteria of HRS and whose serum creatinine value (SCr) doubled at 2.5 mg/dL or greater within 2 weeks or whose 24h creatinine clearance (Ccr) decreased by half at less than 20 mL/min.
• •Patients should meet all the following 5 criteria:
• •\[Modified International Ascites Club's Diagnostic criteria of HRS\]
• •1. Chronic or acute liver disease with advanced hepatic failure and portal hypertension.
• •2. Low glomerular filtration rate (SCr \>1.5 mg/dL or 24h Ccr \<40 mL/min)
• •3. Absence of shock, ongoing bacterial infection, current or recent (within 2 weeks) treatment with nephrotoxic drug
• •4. No sustained improvement in renal function (decrease in SCr to 1.5 mg/dL or less or increase in 24h Ccr to 40 mL/min or more) following diuretic withdrawal and expansion of plasma volume with 1,500 mL/24h of isotonic saline for 24 to 48h.
• •5. Protein urea \<500 mg/dL, and no ultrasonographic evidence of obstructive uropathy or parenchymal renal disease
• •* Age; 20 to 79 years