histologically confirmed, primary pancreatic cancer of the pancreatic head
judged as gross completely resectable
absence of lymph node metastases at the splenic hilum or along the pancreatic tail
no evidence of distant metastases
age \> 50 years
Karnofsky performance score ≥ 70%
adequate bone marrow function (neutrophils \> 2000/µl, platelets \> 100000/µl)
adequate renal function (Creatinine \< 1.5 mg/dl)
adequate liver function
You may not be if
missing written informed consent
missing histological conformation of pancreatic cancer
judged as gross incomplete or not resectable
pancreatic cancer located in the pancreatic corpus or tail
recurrent pancreatic cancer
incomplete staging
presence of lymph node metastases along the pancreatic tail or splenic hilum
presence of distant metastases
prior radiation therapy to the upper abdominal region
neoadjuvant chemotherapy or immunotherapy
participation in another clinical interventional study
age ≤ 50 years
other previous or active malignancy (excluding basal cell carcinoma, carcinoma in situ of the cervix)
Karnofsky performance score \<70%
inadequate bone marrow function
inadequate renal or liver function
any other disease or situation, which generally prohibits the use of major surgery or radiation therapy according to the judgement of a surgeon or radiation oncologist
inability to participate in regular follow up
pregnancy, inability or incompliance for adequate contraception
missing ability to give informed consent
legal custody
Clareo Health | Trial of Neoadjuvant Short Course IMRT Followed by Surgery and IORT for Resectable Pancreatic Cancer
