Xanthohumol and Metabolic Syndrome

Inclusion Criteria

• •BMI 18-32 kg/m2 (to avoid confounders with extreme obesity).
• •Smoking or non-smoking.
• •Having normal or clinically acceptable physical examination and clinical laboratory tests.
• •Willing to abstain from beer consumption for four days prior to and during the study because beer contains XN and related prenylated (PN) flavonoids, such as IX, 8-PN and 6-PN.
• •Not currently taking prescription drugs.
• •Not having had acute medical conditions, such as hospitalizations or surgeries, at least three months prior to entry into the study.
• •If female, not pregnant (as confirmed by urine pregnancy test), breastfeeding, or planning to become pregnant before completing the study, and using effective method of contraception (hormonal methods NOT permitted).
• •If male with a partner of childbearing potential, willing to inform their partner of their participation in this clinical study and use highly effective methods of birth control during the study.
• •Not currently following an extreme diet, such as Atkin's, Zone or Ornish, and willing to maintain their current diet without extreme changes for the duration of the study.