Effect of Methylnaltrexone (MNTX) on Electrocardiogram (ECG) Parameters and Cardiac Repolarization

Exclusion Criteria

• •1. Previous MNTX exposure
• •2. Currently pregnant or nursing
• •3. History or presence of cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, neurological, or other medically significant disorders
• •4. Consumption of alcoholic beverages within 7 days prior to study confinement
• •5. Any evidence of congenital or familial long-QT syndrome
• •6. History of drug abuse of positive findings on urine drug screen
• •7. Known allergy or hypersensitivity to MNTX or its excipients, moxifloxacin, opioids, or related drugs or a history or relevant adverse drug reactions of any origin.