Bicarbonate for Tumor Related Pain

Exclusion Criteria

• •Patients with renal insufficiency (creatinine \> 2.5 mg/dL) are excluded
• •Patients with history of congestive heart failure or pulmonary artery hypertension will be excluded
• •Any patient who in the opinion of the investigator is dehydrated at the time of initial evaluation will be excluded.
• •Patients with uncontrolled hypertension (systolic pressure \>140, diastolic pressure \>90) despite maximal antihypertensive therapy.
• •Patients unable to ingest of oral sodium bicarbonate (such as patients with dysphagia or severe nausea)
• •Patients with ECOG performance status 4
• •Patients with estimated survival less than 3 months
• •Patients with known allergy to sodium bicarbonate or patients with preexisting renal or acid base disorders for which sodium bicarbonate is contraindicated (such as metabolic alkalosis, severe congestive heart failure, hypernatremia, and hypocalcemia \[see above\]).
• •Patients with severe ongoing infections which places the patients at increased risks from therapy in the opinion of the investigator.
• •Patients who are receiving and or will receive, during their participation in study, an oral chemotherapeutic agent whose bioavailability could be altered by the ingestion of sodium bicarbonate.