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Keep this study
Lead
University Hospital, Tours
With
Institut National de la Santé Et de la Recherche Médicale, France
Pre-eclampsia (PE) and intrauterine growth restriction (IUGR) are known as major factors in perinatal morbidity and mortality. Routine antenatal care is focused on the detection of women at increased risk to apply this population a program of careful monitoring and appropriate intervention.
Uterine artery Doppler during anomaly scan at 12 to 14 weeks in selected women at increased risk, has proved to be accurate to detect those who will develop PE or IUGR during the second half of pregnancy.
A variety of angiogenic proteins have been studied as potential markers for pre-eclampsia. Among these protein Plgf and sflt-1 have respectively demonstrated higher and lower levels in pregnant women who will subsequently develop pre-eclampsia.
Our study is aimed to evaluate the performance of serum Plgf and sflt-1 measurement in association with uterine artery Doppler as a screening for placental insufficiency.
Age
18–any
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
Chronic hypertension under medication
Insulin or not insulin dependant preexisting diabetes
Previous history of pre-eclampsia
Previous history of unexplained stillbirth
Previous history of placental abruption
Previous history of SGA (\< 10th centile)
History of pre-eclampsia or chronic hypertension before 45 years in the mother or a sister
History of vascular pathology before 50 years in the father
Obesity (BMI\>26)
Nulliparous after 38 years
Assisted conception with donor
Primipaternity after 38 years old or before 20 years old
