Evaluating Cerebrospinal Fluid Biomarkers in Alzheimer's, Progressive Supranuclear Palsy Subjects, and Controls

Inclusion Criteria

• •All subjects
• •Body Mass Index of 18-32.
• •Subjects can have common non-neurological age-related disorders (hypertension, diabetes) and on stable medication for the last 3 months.
• •Screening score of \< 4 on the Modified Hachinski Ischemia Scale.
• •Women not of childbearing potential and men.
• •Women with negative pregnancy test prior to starting heavy water and not breastfeeding.
• •AD
• •Diagnosis of probable AD.
• •Mild to moderate disease severity according to mini-mental state examination score (MMSE) of 16-26.
• •Documented cognitive decline began 6 months prior to screening.
• •On stable doses of approved AD medications for 2 months prior to screening.
• •Non-medicated AD subjects are free of AD medications for 2 months prior to screening.
• •Mild to moderate white matter disease and up to 2 lacunar infarcts acceptable as determined by brain MRI at screening.
• •Investigator determines subjects to be medically stable and physically able to complete the study.
• •Minimum of 6 years of education and able to read, write and communicate effectively.
• •Adequate hearing, vision, and language skills.
• •Subjects and their caregivers must agree to the dosage regimens and procedures, report for scheduled visits, and communicate with study personnel.
• •PSP
• •Diagnosis of probable PSP.
• •Brain MRI at screening excluding potential causes of parkinsonism, especially cerebrovascular and space occupying lesions.
• •Mild-to-moderate stage of disease severity by a Golbe Staging System score of 1-3.
• •Subjects and their caregivers must agree to the dosage regimens and procedures, report for scheduled visits, and communicate with study personnel.
• •Currently on stable doses of PSP medications for 2 months prior to screening.
• •Investigator determines subjects to be medically stable and able to complete the study.
• •Minimum of 6 years of education and able to read, write and communicate effectively.
• •Adequate hearing, vision, and language skills.
• •EHV
• •No clinically significant deviation from healthy for their age group.
• •No subjective or objective memory loss.
• •MMSE score of 28 to 30.