High Dose Intensity Modulated Proton Radiation Treatment +/- Surgical Resection of Sarcomas of the Spine, Sacrum and Base of Skull

Inclusion Criteria

• •Pathological diagnosis of chondrosarcoma of the spine or sacrum or chordoma of the base of skull, spine or sacrum. Pathologic diagnosis to be confirmed at MGH or other participating institution.
• •Participants need not have measurable disease. Lesion may be primary or recurrent after prior surgery. Patient tumor status: 1) Status post biopsy only and no further surgery planned, 2) Status post resection with gross residual disease, 3) Status post grossly complete research but with margins positive or close (10mm or less), 4) Status post biopsy and patient to have additional surgery and radiation
• •No prior radiation treatment to the affected skull base, spine, or sacral region. Prior chemotherapy is allowed within 30 days of start of treatment
• •18 years of age or older
• •ECOG Performance Status of 0, 1 or 2
• •NOrmal organ and marrow function as outlined in the protocol
• •No clinical, radiographic or other evidence of distant metastasis
• •Women of child-bearing potential and men must agree to use adequate contraception prior to study entry and for the duration of study participation
• •HIV-positive individuals on combination antiretroviral therapy