Add on Lacosamide Versus High Dose Monotherapy

Exclusion Criteria

• •1. Clinical suspicion of nonepileptic psychogenic seizures or idiopathic generalized epilepsy
• •2. Pregnant, child-bearing age not using contraception, or breast feeding
• •3. Medical contraindication to adding lacosamide
• •4. History of antiepileptic drug (AED) polytherapy
• •5. Presence of a vagus nerve stimulator
• •6. Creatinine clearance of less than 50 mL/min
• •7. Blood pressure instability: pulse \<50 or \>100, systolic blood pressure (SBP) \<50 or \>180, clinically significant electrocardiogram (EKG) abnormality
• •8. History of significant drug rash or anaphylactic reaction with antiepileptic drug
• •9. Patients with progressive lesions (e.g. brain tumors)