Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Johns Hopkins University
Age
18–100
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
TBI (Moderate/Severe TBI (GCS 12 or Head AIS\>1) or hemorrhagic neurologic injury
Hyperadrenergic Activity: At least one paroxysmal episode (lasting at least 15 minutes) of Heart Rate 110 beats per minute during two or more consecutive days plus at least two more of the following that may not be better explained by another disease process (ex: sepsis):
Temperature of 38.5C Respiratory Rate 20 breaths per minute Agitation Diaphoresis Dystonia Stimulus responsive ("triggering of paroxysm")
\- Informed Consent obtained
You may not be if
Patients that do not meet criteria for dysautonomia (as stated above)
Age \<18 years
Pregnancy
Hypotension - requiring pressor therapy to maintain baseline adequate CPP or mean arterial pressure
Cardiac arrhythmia - sinus bradycardia (HR \<60), 2nd or 3rd degree AV block
Hemodynamic contraindications to intravenous beta-blockade such as a documented history of congestive heart failure (CHF), dependency on cardiac inotropes or documented bronchospastic disease
Any patient on chronic beta blockade as an outpatient.
Life expectancy \< 48 hours or patients with "do not resuscitate orders"
