Cholesterol Metabolites as Markers for CYP3A Induction

Inclusion Criteria

• •1. Females and males.
• •2. Age of 18 and above.
• •3. Caucasians.
• •4. Healthy as assessed by medical history and examination by principal investigator or delegated personnel.
• •5. Accept to refrain from herbal drugs, natural preparations, and grapefruit juice 48 hours before and during the study period.
• •6. Accept to completely refrain from alcohol during day -1 to 1 and R14-R16. During the rest of the study moderate alcohol use is permitted (equal to 1 glass of wine or 1 beer per day).
• •7. Women of childbearing age should accept using a reliable barrier contraceptive method throughout the study.
• •8. Women of childbearing age should have a negative pregnancy test at the screening visit.
• •9. Capable of following given instructions.
• •10. Has given written informed consent after receiving both oral and written study information.