Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Turku
Age
18–55
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
age 18 to 55 years
remitting-relapsing multiple sclerosis according to McDonald criteria who fulfill the reimbursement criteria for interferon-beta and have used interferon-beta-1b for at least one month
EDSS (expanded disability statsu scale) ≤ 5
no neutralising antibodies to INFB as measured by indirect MxA test
prepared and considered to follow the protocol
using appropriate contraceptive methods (women of childbearing potential)
has given informed consent
You may not be if
serum calcium \>2.6 mmol/L
serum 25(OH)D2 (kalsidiol) \> 85 nmol/L
presence of primary hyperparathyroidism (serum intact PTH, parathyroid hormone)\>65 ng/L)
pregnancy or unwillingness to use contraception
alcohol or drug abuse
use of glucocorticoid treatment other than intravenous methylprednisolone for treatment of relapses
current use of other immunomodulatory therapy than interferon-beta-1b
known allergy to cholecalciferol or arachis oil (peanuts)
therapy with digitalis, calcitonin or active vitamin D3 analogues during the previous 12 months or multivitamins containing vitamin D during previous two weeks preceding study entry
any condition predisposing to hypercalcaemia (such as any type of cancer)
sarcoidosis
nephrolithiasis or renal insufficiency, serum creatinine above 1.5 times the normal upper reference limit
