Lantus Versus Humalog Mix as add-on Therapy in Type Diabetes Patients Failing Sulfonylurea and Metformin Combination Treatment

Exclusion Criteria

• •Patients, who have had stroke, MI, coronary artery bypass graft (CABG), percutaneous transluminal coronary angioplasty (PTCA) or angina pectoris within the last 12 months.
• •Patients with congestive heart failure requiring pharmacological treatment.
• •Patients on non-selective beta blockers (including ocular).
• •Patients with impaired renal function, as shown by but not limited to serum creatinine ≥ 1.5 mg/dl (133μmol/L) for males, or ≥ 1.4 mg/dl (124 μmol/L) for females.
• •Patients with acute infections.
• •Patients with diagnosis of dementia.
• •Treatment with systemic steroids or large doses of inhaled steroids.
• •Patients with acute or chronic metabolic acidosis, including diabetic ketoacidosis.
• •Patients with planned radiological examinations requiring administration of contrasting agents.
• •Clinical evidence of active liver disease, or serum ALT 2.5 times the upper limit of the normal range.
• •Patients with history of hypoglycemia unawareness.
• •Pregnant or lactating females.
• •Failure to use adequate contraception (women of current reproductive potential only).
• •The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.