Curcumin Biomarkers

Exclusion Criteria

• •1. Familial colorectal cancer syndromes (e.g. Hereditary Non-Polyposis Colon Cancer, Familial Adenomatous Polyposis)
• •2. Ulcerative colitis or Crohn's disease.
• •3. History of large bowel resection for any reason
• •4. Diagnosed narcotic or alcohol dependence
• •5. Unwillingness to forgo curcumin/turmeric-containing supplements during the trial or consumption of curry/turmeric at meals \> 3 times a week.
• •6. Allergy to turmeric/curcumin.
• •7. Women with childbearing potential who do not agree to practice effective birth control.
• •8. Individuals with creatinine, AST or ALT above 1.5 times the upper limit of normal at baseline.
• •9. Personal or inherited bleeding disorders or therapeutic anti-coagulation with warfarin.
• •10. Women who are pregnant or nursing.
• •11. Individuals who have taken antibiotics within the three months prior to enrollment.