Lead Sponsor

United States Department of Defense

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•1. Adult males or females ≥ 18 years of age
•2. Subjects with Traumatic Brain Injury and a post-resuscitation Glasgow Coma Score (GCS) ≤ 8
•3. In-hospital and screened within 7 hours of injury.
•4. Able to obtain legally effective written consent from authorized representative
•5. Patients who are intubated and on mechanical ventilation
•6. Admitted to ICU

•1. Bladder or rectal core temperature below 32C (89.6F) upon admission
•2. Clinical brain death
•3. Patients with open abdomens.
•4. Multiple orthopedic injuries (\> 2 long bone fractures)
•5. Persistent hypotension (systolic blood pressure \< 90mmHg)
•6. Persistent hypoxia (O2 Saturation \< 94%)
•7. Persistent metabolic acidosis (Lactic acid \> 5 mmol/L, arterial pH \< 7.25)
•8. Positive serum pregnancy test
•9. Cardiac arrhythmia with deleterious hemodynamic effects; heart block or myocardial damage (as shown on ECG)
•10. History of abnormal renal function
•11. Significant Co-morbidity (i.e. CAD;COPD; severe coagulopathy)
•12. Pediatric patients (\< 18 years old)

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