Cardiovascular Risk Reduction Study (Reduction in Recurrent Major CV Disease Events)

Exclusion Criteria

• •Pregnant or nursing (lactating) women
• •Women of child-bearing potential
• •Any of the following concomitant diseases
• •Planned coronary revascularization (PCI or CABG)
• •Major non-cardiac surgical or endoscopic procedure within past 6 months
• •Multi-vessel CABG surgery within the past 3 years
• •Symptomatic patients with Class IV heart failure (HF) (New York Heart Association \[NYHA\].
• •Uncontrolled hypertension
• •Uncontrolled diabetes
• •History or evidence of active tuberculosis (TB) infection Substudy 1 Exclusion
• •All Main exclusion
• •Patients with prior history of carotid angioplasty, stenting, or carotid atherectomy
• •Patients with contraindications to MRI examination (brain aneurysm clip, implanted neural stimulator, implanted cardiac pacemaker, pacemaker wires or defibrillator, prosthetic heart valves, cochlear implant, ocular foreign body or other implanted body, tattoos, implanted insulin pump, metal shrapnel or bullet)
• •Patients prone to claustrophobia or known anxiety disorders
• •BMI \> 40 kg/m2 Substudy 2 Exclusion