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COMPLETEDNCT01322074

Systemic Inflammation Versus Acute Pain in Total Knee Arthroplasty (TKA)

In this study we evaluate if there is a correlation between acute pain and systemic inflammatory markers after total Knee Arthroplasty (TKA).

Lead sponsor: Hvidovre University Hospital•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Hvidovre University Hospital

The correlation between acute pain and systemic inflammatory markers after total Knee Arthroplasty (TKA) is evaluated. Level of systemic inflammatory markers (CRP and IL6) are measured preoperatively and 4 and 24 hours postoperatively. These measurements are correlated to postoperative pain (a detailed assessment of pain at rest and during ambulation). We pole blood-samples collected prospectively (from two data set)

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Elective unilateral primary total knee arthroplasty
•Able to speak and understand danish
•Able to give informed consent

Exclusion Criteria

•Alcohol or medical abuse
•Allergies to local anesthetics or methylprednisolone
•Age \< 18 years old
•Daily use of strong opioids or glucocorticoids
•Pregnancy or breastfeeding (fertile women)
•Bilateral / revision arthroplasty
•Dementia or other cognitive dysfunction
•Diabetic neuropathy, rheumatoid arthritis, and neurologic or psychiatric diseases potentially influencing pain perception

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: October 17, 2011Terms

Trial snapshot

StatusCOMPLETED

Phase—

Enrollment120

Start dateAug 2009

Last updatedOct 17, 2011

Condition

Other Acute Postoperative Pain Systemic Inflammatory Response Syndrome

Locations shown

Dep. of Anesthsiology, Hvidovre University Hospital

Copenhagen, Hvidovre

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 17, 2011Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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