Glivec in Prostate Cancer Patients With Rising PSA Following Radical Prostectomy

Inclusion Criteria

• •who are 18 years of age or older.
• •who have undergone radical prostatectomy within 2 years prior to PSA progression .
• •exhibiting two consecutive rises in PSA levels relative to a previous reference value, separated by 14 days.
• •The first measurement must occur 14 days after the reference value und must be at least 20% above the reference value. The reference value must be at least 0.4 ng/ml. The second confirmatory measurement taken 14 days after the first measurement must be greater than the first measurement.
• •with a Karnofsky Performance Score (KPS) greater than or equal to 90 (Appendix 5).
• •with the following hematologic lab values: ANC greater than or equal to 1500/mm3, Hgb greater than or equal to 10g/dL, PLT greater than or equal to 100x109/L.
• •with the following biochemistry lab values: total bilirubin \< 1.5 ULN, SGOT, SGPT less than or equal to 2.5 ULN, serum creatinine less than or equal to 1.5 ULN.
• •willing to employ an effective barrier method of contraception during the study duration and for 3 months following discontinuation of study drug (for patients of reproductive potential).
• •with a life expectancy of \> 6 months.
• •who have provided written informed consent pursuant to local regulatory requirements prior to initiation of any study procedure.
• •with a Gleason Score \> 6 in the prostatectomy specimen