* Inclusion of affected subjects with familial history of chronic renal failure, early gout ,renal cysts in several hospital in France
* Characterization of the phenotype; dosage of the urinary uromodulin in all subjects
* Collect DNA samples
* Screen for UMO mutations first
* Then for REN or TCF2 depending on the phenotype
* Validate the use of the dosage of urinary uromodulin for the diagnosis of UMOD associated disease.
* Identify new genes responsible for hereditary HTIN (Hereditary Tubulointerstitial Nephritis).
