Age

18–any

Sex

ALL

Healthy volunteers

Not accepted

Pregnant women and nursing mothers
Conditions or medications associated with an increased risk of bleeding/complications from anticoagulation
Previous episode of sepsis during this hospitalization
PaO2/FiO2 ratio \< 300
Severe granulocytopenia (leukocytes \<500 / μl)
Acute hepatic diseases or severe liver failure or cirrhosis
Chronic cardiovascular disease precluding extracorporeal treatment
Human immunodeficiency virus complicated by AIDS defining illness
Evidence of active bleeding - uncontrolled hemorrhage

S.A.F.E.BT System Extracorporeal Treatment With DIAPACT CRRT