Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
AstraZeneca
Age
18–55
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Provision of informed consent prior to any study specific procedures (including genotyping screening sample for CYP2C9 and VKORC1).
Males or females (of non-childbearing potential) aged 18 to 55 years (inclusive)
Subjects must be negative for occult blood (stool card) prior to administration.
Body weight of at least 50 kg and body mass index (BMI) between 18 and 35 kg/m2 inclusive
You may not be if
History of any clinically significant disease or disorder which, in the opinion of the Investigator, may put the subject at risk because of participation in the study, or influence the results of the study.
Healthy subject predicted to be most sensitive to warfarin based on CYP2C9 and VKORC1 genotypes.
A protein C and/or protein S deficiency.
Absolute neutrophil count of less than 2500/mm3 or 2.5 x 109/L
Previous treatment with warfarin for a clinical indication (ie, participation in a previous warfarin interaction study is acceptable).
Clareo Health | Effects of Administration of Fostamatinib on Blood Concentrations of Warfarin in Healthy Subjects
