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Does Pregabalin Improve Symptoms of Anxiety in Patients With Epilepsy? A Comparison With Sertraline | Clinical Trials | Clareo Health

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Does Pregabalin Improve Symptoms of Anxiety in Patients With Epilepsy? A Comparison With Sertraline

NCT01309074•Rush University Medical Center

View on ClinicalTrials.gov

Summary

The aim of the study is to compare the safety \& efficacy of sertraline (up to a dose of 200mg/day) \& pregabalin (up to a dose of 300mg/day) for the treatment of symptoms of anxiety in patients with epilepsy.

Detailed Description

Patients with epilepsy will be treated with either sertraline (up to a dose of 200mg/day) or pregabalin (up to a dose of 300mg/day) for the treatment of symptoms of anxiety. Outcome measures will include changes in the anxiety severity scales.

Eligibility

Age

18 - 80 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•GAD-7 total score above 10.
•Have a diagnosis of a Partial Seizure Disorder.
•Have a Hamilton-A total score 20 and above.
•18-80 years of age.
•Able to read at a fourth grade level.
•If a woman of childbearing age, agrees to use an acceptable means of birth control.

Exclusion Criteria

•Unable to understand and sign a consent.
•Unable to follow instructions for the study.
•Displaying current suicidal ideation
•Having psychogenic non-epileptic seizures
•Have a history of drug or alcohol abuse.
•Use of any investigational drug within the last 30 days.
•Hypersensitivity reaction or other serious adverse event to PGB in prior trials.

Locations (1)

Rush University Medical Center

Chicago, Illinois, United States

Key Dates

Start Date

November 1, 2009

Primary Completion Date

December 1, 2012

Completion Date

December 1, 2012

Last Updated

February 2, 2023

Conditions

EpilepsyAnxiety

Interventions

Pregabalin-Lyrica

DRUG

Sertraline

DRUG

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 2, 2023Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Does Pregabalin Improve Symptoms of Anxiety in Patients With Epilepsy? A Comparison With Sertraline

Inclusion Criteria

Exclusion Criteria

Thalamus Seizure Detection With a Deep Brain Stimulator System

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