Anidulafungin vs Amphotericin B Safety in High Risk Hepatic Transplant Recipients

Inclusion Criteria

• •At least 18 years old
• •Signature of ICF
• •Negative pregnancy test (women of child bearing potential)
• •Patients who comply with at least one of the following (A or B):
• •A: One of the following criteria (major criteria):
• •Re-transplant due to severe dysfunction of a previous hepatic graft
• •Requirement of any renal substitutive therapy, including dialysis or hemofiltration
• •Fulminant hepatitis requiring hepatic transplant
• •B: Two of the following criteria (minor criteria):
• •Post-transplant renal impairment (defined as CrCl\< 50 mL/min) 30 days after transplantation
• •Intra surgery blood transfusion of at least 40 units
• •Choledochal jejunectomy
• •2 or more Candida sp cultures (nasal, pharynx, rectal) from 48 hours pre- to 48 hours post-hepatic transplant
• •Post transplant re-intervention (laparotomy)