Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Instituto Nacional de Cancer, Brazil
Patients will take metformin twice a day for 3 weeks before surgery. The hypothesis is that metformin will reduce cell proliferation rates (Ki67) and increase apoptoses (TUNEL)in tumor tissue.
The study will collect and analyze pre- and post-treatment blood specimens for:
* Serum glucose
* Insulin levels
* Estradiol
* HOMA test
* Glycosylated haemoglobin
Age
18–any
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
Invasive breast cancer T1 or T2, Nx
Knowledge of the investigational nature of the study and ability to provide consent for study participation
You may not be if
Diabetes or baseline glucose or Glycosylated haemoglobin upper limit of normal for the institution
Recent use of corticosteroids
AST \> 1.5 times upper limit of normal for the institution
Pregnancy
Serious clinical illness
Prior or concurrent systemic neoadjuvant Breast Cancer therapy.
Clareo Health | The Use of Metformin in Early Breast Cancer Patients Pre-Surgery
