Lead Sponsor

AstraZeneca

Collaborators

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Yes

•Is overtly healthy, as determined by medical history and physical examination
•Has body mass index (BMI) between 25 and 35 kg/m2
•Has fasting serum glucose \<110 mg/dL
•Has no clinically significant blood pressure or heart rate readings as judged by the investigator at study start
•Has electrocardiogram (ECG) results judged as not clinically significant by the investigator at study start

•Has a clinically significant medical condition that could potentially affect study participation and/or personal well-being
•Has an abnormality in the 12-lead ECG that, in the opinion of the investigator, increases the risk of participating in the study, such as a Bazett's corrected QT (QTcB) interval \>450 ms.
•Family history of sudden death
•Personal history of unexplained syncope within last year, or family history of Long QT Syndrome, or significant active cardiac disease, or symptoms of angina pectoris or transient ischemic attacks within the previous 6 months

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