Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Genta Incorporated
Age
18–any
Sex
MALE
Healthy volunteers
Not accepted
You may be eligible if
At least 18 years of age
Histologically confirmed prostate cancer, currently with progressive disease
Evidence of metastatic disease
Castrate level of testosterone (\< 50 ng/dL)
Eastern Cooperative Oncology Group performance status 0 or 1
Chemotherapy-naïve
Adequate bone marrow, hepatic, and renal function
Ability to swallow an oral solid-dosage form of medication
You may not be if
History or presence of brain metastasis or leptomeningeal disease
Operable cancer
Uncontrolled diarrhea
Uncontrolled nausea or vomiting
Known malabsorptive disorder
Currently active second malignancy other than non-melanoma skin cancers
Human immunodeficiency virus (HIV) infection based on history of positive serology
Significant medical disease other than cancer
Presence of neuropathy \> Grade 2 (National Cancer Institute Common Toxicity Criteria \[NCI CTC\]; v4.0)
Need for other anticancer treatment
Need to continue any regularly-taken medication that is a potent inhibitor or inducer of the CYP3A pathway or P-glycoprotein activity
Less than 2 weeks since use of a medication or ingestion of an agent, beverage, or food that is a potent inhibitor or inducer of the CYP3A pathway or P-glycoprotein activity
Less than 4 weeks since use of another investigational agent
