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The Effects of Radiation Therapy on the Reconstructed Breast: An Evaluation Using MR Imaging
The primary objective of this study is to use LR imaging to evaluate the effects of adjuvant radiation therapy on reconstructed breasts.
Immediate breast reconstruction following mastectomy has become an increasingly popular and accepted treatment option among breast cancer patients. This change in practice has resulted in a significant number of patients who undergo radiation therapy after breast reconstruction. Following irradiation, the reconstructed breast often experiences fibrotic contracture, volume loss, altered pigmentation, or some combination thereof, producing an asymmetric and aesthetically compromised result. The effects of radiation on reconstructed breasts as well as the implications that such changes have for timing of reconstructive surgery, post-operative management and surveillance imaging are topics of growing importance in plastic surgery, radiology and surgical oncology.
Age
18 - 90 years
Sex
FEMALE
Healthy Volunteers
No
Abramson Cancer Center of the University of Pennsylvania
Philadelphia, Pennsylvania, United States
Start Date
December 1, 2010
Primary Completion Date
December 1, 2016
Completion Date
May 5, 2019
Last Updated
April 8, 2020
12
ACTUAL participants
contract-enhanced MRI
PROCEDURE
Unilateral Adjuvant Radiation Therapy
RADIATION
Lead Sponsor
Abramson Cancer Center at Penn Medicine
NCT04704661
NCT05372640
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